LYMPHOID NEOPLASIA PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia
نویسندگان
چکیده
1Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium; 2Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium; 3Inserm U944 and Hematology Laboratory, Hôpital Saint-Louis, Institut Universitaire d’Hématologie, Université Paris Diderot, Paris, France; 4National Center for Scientific Research (CNRS) Unité Mixte de Recherche (UMR) 8147 and Department of Hematology, Hôpital Necker-Enfants-Malades Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-5 Descartes, Paris, France; 5Ludwig Institute for Cancer Research, Brussels, Belgium; 6de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; 7Division of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; 8Department of Pediatrics, Erasmus Medical Center-Sophia, Rotterdam, The Netherlands; 9Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; 10Division of Hematology, Department of Cellular Biotechnologies and Hematology, La Sapienza University of Rome, Rome, Italy; and 11Munich Leukemia Laboratory, Munich, Germany
منابع مشابه
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.
We have recently reported inactivation of the tyrosine phosphatase PTPN2 (also known as TC-PTP) through deletion of the entire gene locus in ∼ 6% of T-cell acute lymphoblastic leukemia (T-ALL) cases. T-ALL is an aggressive disease of the thymocytes characterized by the stepwise accumulation of chromosomal abnormalities and gene mutations. In the present study, we confirmed the strong associatio...
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